When flower store assistant Seymour Krelborn stumbles upon a very strange new plant species, he has high hopes that his discovery will lead to fame, fortune and the heart of his unrequited crush, Audrey. But Seymour gets a whole lot more than he bargained for from this exotic foliage. After an accident, the cute little Audrey II (named for his beloved) develops an insatiable thirst for human blood and a set of R&B singing pipes, leading Seymour to turn serial killer to keep his secret from bursting out of Skid Row and endangering the whole human race!